![Anti-CD230/PRNP nanobody [SAA0870] (STJN000093)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200706/412888/STJN000093-SDS-PAGE-1__06116.1749232429.jpg?c=1 "Anti-CD230/PRNP nanobody [SAA0870] (STJN000093)")
![Anti-CD230/PRNP nanobody [SAA0870] (STJN000093)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200706/412888/STJN000093-SDS-PAGE-1__06116.1749232429.jpg?c=1 "Anti-CD230/PRNP nanobody [SAA0870] (STJN000093)")
Anti-CD230/PRNP nanobody [SAA0870] (STJN000093)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Major Prion Protein is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0870 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | PRNP |
| Gene ID | 5621 |
| Uniprot ID | PRIO_HUMAN |
Additional Info
| Function | Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains. |
| Protein Name | Major Prion ProteinPrpAscrPrp27-30Prp33-35cCd Antigen Cd230 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-9609523 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorGolgi ApparatusTargeted To Lipid Rafts Via Association With The Heparan Sulfate Chains Of Gpc1ColocatesIn The Presence Of Cu(2+)To Vesicles In Para- And Perinuclear RegionsWhere Both Proteins Undergo InternalizationHeparin Displaces Prnp From Lipid Rafts And Promotes Endocytosis |
| Alternative Nanobody Names | Anti-Major Prion Protein nanobodyAnti-Prp nanobodyAnti-Ascr nanobodyAnti-Prp27-30 nanobodyAnti-Prp33-35c nanobodyAnti-Cd Antigen Cd230 nanobodyAnti-PRNP nanobodyAnti-ALTPRP nanobodyAnti-PRIP nanobodyAnti-PRP nanobody |
Information sourced from Uniprot.org