Anti-CD230 antibody [POM6] {FITC} (STJA0028023)

SKU:
STJA0028023
€318.13 - €473.13
Free Shipping
Processing The item has been added

Host: Rat
Applications: ELISA/FC
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Short Description : Rat monoclonal antibody anti-Major Prion Protein is suitable for use in ELISA and Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : POM6
Conjugation: FITC
Isotype: IgG1k
Formulation: 0.01M PBS, pH 7.4, 02% BSA, 0.05% Proclin 300
Purification: Purified
Concentration: 05 mg/mL
Storage Instruction: Store at 4°C for 12 months Protect from light Do not freeze
Gene Symbol: Prnp
Gene ID: 19122
Uniprot ID: PRIO_MOUSE
Post Translational Modifications N-glycosylated.
Function Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
Protein Name Major Prion Protein
Prp
Prp27-30
Prp33-35c
Cd Antigen Cd230
Database Links Reactome: R-MMU-9609523
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Golgi Apparatus
Targeted To Lipid Rafts Via Association With The Heparan Sulfate Chains Of Gpc1
Colocates
In The Presence Of Cu(2+)
To
Vesicles In Para- And Perinuclear Regions
Where Both Proteins Undergo Internalization
Heparin Displaces Prnp From Lipid Rafts And Promotes Endocytosis
Alternative Antibody Names Anti-Major Prion Protein antibody
Anti-Prp antibody
Anti-Prp27-30 antibody
Anti-Prp33-35c antibody
Anti-Cd Antigen Cd230 antibody
Anti-Prnp antibody
Anti-Prn-p antibody
Anti-Prp antibody

Information sourced from Uniprot.org