| Host: |
Rat |
| Applications: |
FC |
| Reactivity: |
Mouse |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rat monoclonal antibody anti-Cd226 antigen is suitable for use in Flow Cytometry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
10E5 |
| Conjugation: |
PE |
| Isotype: |
IgG2bk |
| Formulation: |
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Purification: |
Affinity purified |
| Storage Instruction: |
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Post Translational Modifications | Phosphorylated. Phosphorylation of Tyr-319 allows GRB2 binding and activation of subsequent signaling. |
| Function | Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells. Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells. Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes. |
| Protein Name | Cd226 AntigenPlatelet And T-Cell Activation Antigen 1Cd Antigen Cd226 |
| Database Links | Reactome: R-MMU-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLocalizes To Lipid Rafts |
| Alternative Antibody Names | Anti-Cd226 Antigen antibodyAnti-Platelet And T-Cell Activation Antigen 1 antibodyAnti-Cd Antigen Cd226 antibodyAnti-Cd226 antibodyAnti-Pta1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
