Anti-CD215/IL-15R alpha antibody [SRM13247] (STJ11107977)

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STJ11107977
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Host: Rabbit
Applications: WB/FC/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : SRM13247
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS containing 50% Glycerol and 0.05% BSA, preserved with proclin300 or Sodium Azide (as specified on the Certificate of Analysis) , pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB, 1:2000-1:10000
FC, 1:500-1:1000
ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IL15RA
Gene ID: 3601
Uniprot ID: I15RA_HUMAN
Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Immunogen Sequence: Human
Post Translational Modifications N-glycosylated and O-glycosylated. A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
Function High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. In neutrophils, binds and activates kinase SYK in response to IL15 stimulation. In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5: Does not bind IL15. Isoform 6: Does not bind IL15. Isoform 7: Does not bind IL15. Isoform 8: Does not bind IL15.
Protein Name Interleukin-15 Receptor Subunit Alpha
Il-15 Receptor Subunit Alpha
Il-15r-Alpha
Il-15ra
Cd Antigen Cd215 Cleaved Into - Soluble Interleukin-15 Receptor Subunit Alpha
Sil-15 Receptor Subunit Alpha
Sil-15r-Alpha
Sil-15ra
Database Links Reactome: R-HSA-8983432
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Nucleus Membrane
Cell Surface
Mainly Found Associated With The Nuclear Membrane
Isoform 5: Endoplasmic Reticulum Membrane
Golgi Apparatus Membrane
Cytoplasmic Vesicle Membrane
Isoform 5
Isoform 6
Isoform 7 And Isoform 8 Are Associated With Endoplasmic Reticulum
Golgi And Cytoplasmic Vesicles
But Not With The Nuclear Membrane
Isoform 6: Endoplasmic Reticulum Membrane
Isoform 7: Endoplasmic Reticulum Membrane
Isoform 8: Endoplasmic Reticulum Membrane
Soluble Interleukin-15 Receptor Subunit Alpha: Secreted
Extracellular Space
Alternative Antibody Names Anti-Interleukin-15 Receptor Subunit Alpha antibody
Anti-Il-15 Receptor Subunit Alpha antibody
Anti-Il-15r-Alpha antibody
Anti-Il-15ra antibody
Anti-Cd Antigen Cd215 Cleaved Into - Soluble Interleukin-15 Receptor Subunit Alpha antibody
Anti-Sil-15 Receptor Subunit Alpha antibody
Anti-Sil-15r-Alpha antibody
Anti-Sil-15ra antibody
Anti-IL15RA antibody

Information sourced from Uniprot.org

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