Host: | Mouse |
Applications: | FC |
Reactivity: | Human |
Note: | FOR RESEARCH USE ONLY (RUO). |
Short Description : | Mouse monoclonal antibody anti-Complement Receptor Type 2 is suitable for use in Flow Cytometry research applications. |
Clonality : | Monoclonal |
Clone ID : | B-ly4 |
Conjugation: | Unconjugated |
Isotype: | IgG1 |
Formulation: | PBS with 0.2% BSA, and 0.09% Sodium Azide |
Purification: | Protein A purification |
Dilution Range: | Please carry out application specific titration to determine the most appropriate dilution ratio. |
Storage Instruction: | Shipped on gel ice packs. Store at 2-8C on arrival. |
Function | Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Induces also specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner. Acts as a ligand for CD23 (FcepsilonRII), a low-affinity receptor for IgE, which is expressed on B-cells and other immune cells, and thus participates in the regulation of IgE production. (Microbial infection) Acts as a receptor for Epstein-Barr virus. |
Protein Name | Complement Receptor Type 2Cr2Complement C3d ReceptorEpstein-Barr Virus ReceptorEbv ReceptorCd Antigen Cd21 |
Database Links | Reactome: R-HSA-977606 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Complement Receptor Type 2 antibodyAnti-Cr2 antibodyAnti-Complement C3d Receptor antibodyAnti-Epstein-Barr Virus Receptor antibodyAnti-Ebv Receptor antibodyAnti-Cd Antigen Cd21 antibodyAnti-CR2 antibodyAnti-C3DR antibody |
Information sourced from Uniprot.org