| Function | Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF-alpha and leukotriene B4. Also mediates monocyte migration upon CXCL4 binding. Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway. |
| Protein Name | C-C Chemokine Receptor Type 1C-C Ckr-1Cc-Ckr-1Ccr-1Ccr1Macrophage Inflammatory Protein 1-Alpha ReceptorMip-1alpha-RRantes-RCd Antigen Cd191 |
| Database Links | Reactome: R-MMU-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-C-C Chemokine Receptor Type 1 antibodyAnti-C-C Ckr-1 antibodyAnti-Cc-Ckr-1 antibodyAnti-Ccr-1 antibodyAnti-Ccr1 antibodyAnti-Macrophage Inflammatory Protein 1-Alpha Receptor antibodyAnti-Mip-1alpha-R antibodyAnti-Rantes-R antibodyAnti-Cd Antigen Cd191 antibodyAnti-Ccr1 antibodyAnti-Cmkbr1 antibody |
Information sourced from Uniprot.org
