| Host: | Rat |
| Applications: | Cell Sep-Neg/Depletion/Neut/FC/IP |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Rat monoclonal antibody anti-B-lymphocyte antigen CD19 is suitable for use in Universal, Universal, Universal, Flow Cytometry and Immunoprecipitation research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 1D3 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2ak |
| Formulation: | 0.2 µm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as determined by LAL gel clotting assay. |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | Store at 2-8°C. Do not freeze this product. |
| Gene Symbol: | Cd19 |
| Gene ID: | 12478 |
| Uniprot ID: | CD19_MOUSE |
| Tissue Specificity | Detected on B cells in spleen, bone marrow, thymus and lymph nodes. Detected on peripheral blood lymphocytes (at protein level). |
| Post Translational Modifications | Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-522 is extremely rapid, followed by phosphorylation at Tyr-402. In contrast, phosphorylation of Tyr-493 appears more slowly and is more transient, returning rapidly to basal levels. |
| Function | Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge. |
| Protein Name | B-Lymphocyte Antigen Cd19 Differentiation Antigen Cd19 Cd Antigen Cd19 |
| Database Links | Reactome: R-MMU-1257604 Reactome: -MMU-198933 Reactome: -MMU-6811558 Reactome: -MMU-977606 Reactome: -MMU-983695 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft |
| Alternative Antibody Names | Anti-B-Lymphocyte Antigen Cd19 antibody Anti-Differentiation Antigen Cd19 antibody Anti-Cd Antigen Cd19 antibody Anti-Cd19 antibody |
Information sourced from Uniprot.org