• C57BL/6 murine splenocytes were stained with Anti-CD19 antibody (STJA0000022) [Used at 0.05 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained lymphocytes (empty black histogram) were used as control.

Anti-Cd19 antibody [1D3] {PerCP/Cyanine5.5} (STJA0000022)

SKU:
STJA0000022

£133.50 - £268.50
Current Stock:
Host: Rat
Applications: FC
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-B-lymphocyte antigen CD19 is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: 1D3
Conjugation: PerCP/Cyanine5.5
Isotype: IgG2ak
Formulation: PBS with 0.05% Proclin300, 1% BSA
Concentration: 0.2 mg/mL
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: Cd19
Gene ID: 12478
Uniprot ID: CD19_MOUSE
Tissue Specificity Detected on B cells in spleen, bone marrow, thymus and lymph nodes. Detected on peripheral blood lymphocytes (at protein level).
Post Translational Modifications Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-522 is extremely rapid, followed by phosphorylation at Tyr-402. In contrast, phosphorylation of Tyr-493 appears more slowly and is more transient, returning rapidly to basal levels.
Function Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge.
Protein Name B-Lymphocyte Antigen Cd19
Differentiation Antigen Cd19
Cd Antigen Cd19
Database Links Reactome: R-MMU-1257604
Reactome: -MMU-198933
Reactome: -MMU-6811558
Reactome: -MMU-977606
Reactome: -MMU-983695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Alternative Antibody Names Anti-B-Lymphocyte Antigen Cd19 antibody
Anti-Differentiation Antigen Cd19 antibody
Anti-Cd Antigen Cd19 antibody
Anti-Cd19 antibody

Information sourced from Uniprot.org

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