![C57BL/6 murine splenocytes were stained with Anti-CD183/CXCR3 antibody (STJA0000684) [Used at 0.2 ยตg/10<sup>6</sup> cells dilution] and Anti-Mouse CD3 Monoclonal Antibody (AF488 Conjugated). Splenocytes stained with Anti-Mouse CD3 Monoclonal Antibody (AF488 Conjugated) (right) were used as control.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/145537/292195/STJA0000684_1__15261.1631206039.jpg?c=1 "C57BL/6 murine splenocytes were stained with Anti-CD183/CXCR3 antibody (STJA0000684) [Used at 0.2 ยตg/10<sup>6</sup> cells dilution] and Anti-Mouse CD3 Monoclonal Antibody (AF488 Conjugated). Splenocytes stained with Anti-Mouse CD3 Monoclonal Antibody (AF488 Conjugated) (right) were used as control.")
![C57BL/6 murine splenocytes were stained with Anti-CD183/CXCR3 antibody (STJA0000684) [Used at 0.2 ยตg/10<sup>6</sup> cells dilution] and Anti-Mouse CD3 Monoclonal Antibody (AF488 Conjugated). Splenocytes stained with Anti-Mouse CD3 Monoclonal Antibody (AF488 Conjugated) (right) were used as control.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/145537/292195/STJA0000684_1__15261.1631206039.jpg?c=1 "C57BL/6 murine splenocytes were stained with Anti-CD183/CXCR3 antibody (STJA0000684) [Used at 0.2 ยตg/10<sup>6</sup> cells dilution] and Anti-Mouse CD3 Monoclonal Antibody (AF488 Conjugated). Splenocytes stained with Anti-Mouse CD3 Monoclonal Antibody (AF488 Conjugated) (right) were used as control.")
Anti-CD183/Cxcr3 antibody [CXCR3-173] {PE/Cyanine5} (STJA0000684)
SPECIFICATIONS
ClonalityMonoclonal
HostArmenian Hamster
ConjugationPE/Cyanine5
IsotypeIgG
General Information
| Short Description | Armenian Hamster monoclonal anti-C-X-C chemokine receptor type 3 for use in FC in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Armenian Hamster |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | CXCR3-173 |
| Isotype | IgG |
| Conjugation | PE/Cyanine5 |
| Concentration | 0.2 mg/mL |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8ยฐC and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | Cxcr3 |
| Gene ID | 12766 |
| Uniprot ID | CXCR3_MOUSE |
Additional Info
| Tissue Specificity | Expresses in lymphoid organs and Th1 cells. |
| Post Translational Modifications | Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding. N-glycosylated. |
| Function | Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response. Binds to CCL21. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. |
| Protein Name | C-X-C Chemokine Receptor Type 3Cxc-R3Cxcr-3Interferon-Inducible Protein 10 ReceptorIp-10 ReceptorCd Antigen Cd183 |
| Database Links | Reactome: R-MMU-380108Reactome: -MMU-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-C-X-C Chemokine Receptor Type 3 antibodyAnti-Cxc-R3 antibodyAnti-Cxcr-3 antibodyAnti-Interferon-Inducible Protein 10 Receptor antibodyAnti-Ip-10 Receptor antibodyAnti-Cd Antigen Cd183 antibodyAnti-Cxcr3 antibodyAnti-Cmkar3 antibody |
Information sourced from Uniprot.org