Anti-CD18/ITGB2 nanobody [SAA1307] (STJN000102)

Anti-CD18/ITGB2 nanobody [SAA1307] (STJN000102)

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STJN000102
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Short Description :Alpaca monoclonal nanobody anti-Integrin Beta-2 is suitable for use in ELISA research applications.
Applications:ELISA
Host:Alpaca
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SAA1307
Isotype:VHH-8His-Cys-tag
Conjugation:Unconjugated
Concentration:1 mg/mL
Purification:Purified by Nickel column.
Formulation:0.01M PBS, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol:ITGB2
Gene ID:3689
Uniprot ID:ITB2_HUMAN
Post Translational Modifications Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.
Function Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils.
Protein Name Integrin Beta-2
Cell Surface Adhesion Glycoproteins Lfa-1/Cr3/P150 -95 Subunit Beta
Complement Receptor C3 Subunit Beta
Cd Antigen Cd18
Database Links Reactome: R-HSA-166016
Reactome: R-HSA-198933
Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-6785807
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Alternative Nanobody Names Anti-Integrin Beta-2 nanobody
Anti-Cell Surface Adhesion Glycoproteins Lfa-1/Cr3/P150 -95 Subunit Beta nanobody
Anti-Complement Receptor C3 Subunit Beta nanobody
Anti-Cd Antigen Cd18 nanobody
Anti-ITGB2 nanobody
Anti-CD18 nanobody
Anti-MFI7 nanobody

Information sourced from Uniprot.org

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