• Anti-CD163 antibody [MRQ-26] (STJ16100324)

Anti-CD163 antibody [MRQ-26] (STJ16100324)

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STJ16100324

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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD163 is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: MRQ-26
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Dilution Range: IHC 1:10-1:50
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: CD163
Gene ID: 9332
Uniprot ID: C163A_HUMAN
Tissue Specificity Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.
Post Translational Modifications A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. Phosphorylated.
Function Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Protein Name Scavenger Receptor Cysteine-Rich Type 1 Protein M130
Hemoglobin Scavenger Receptor
Cd Antigen Cd163 Cleaved Into - Soluble Cd163
Scd163
Database Links Reactome: R-HSA-2168880
Reactome: R-HSA-9662834
Cellular Localisation Soluble Cd163: Secreted
Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 1 And Isoform 2 Show A Lower Surface Expression When Expressed In Cells
Alternative Antibody Names Anti-Scavenger Receptor Cysteine-Rich Type 1 Protein M130 antibody
Anti-Hemoglobin Scavenger Receptor antibody
Anti-Cd Antigen Cd163 Cleaved Into - Soluble Cd163 antibody
Anti-Scd163 antibody
Anti-CD163 antibody
Anti-M130 antibody

Information sourced from Uniprot.org

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