| Host: |
Rat |
| Applications: |
FC/WB/Block/IHC |
| Reactivity: |
Mouse |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rat monoclonal antibody anti-P-selectin glycoprotein ligand 1 is suitable for use in Flow Cytometry, Western Blot, Universal and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
4RA10 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1k |
| Formulation: |
0.2 µm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as determined by LAL gel clotting assay. |
| Concentration: |
0.5 mg/mL |
| Storage Instruction: |
Store at 2-8°C. Do not freeze this product. |
| Tissue Specificity | Highly expressed in blood, bone marrow, brain, adipose tissue, spleen, and thymus. Also expressed in heart, kidney, liver, muscle, ovary, and stomach. |
| Post Translational Modifications | Displays complex, core-2, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to contain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialylated or neutral forms of the core-2 tetrasaccharide, Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNAcOH. The GlcN:GalN ratio is approximately 2:1 and the Man:Fuc ratio 3:5. Contains about 14% fucose with alpha-1,3 linkage present in two forms: One species is a disialylated, monofucosylated glycan, and the other, a monosialylated, trifucosylated glycan with a polylactosamine backbone. The fucosylated forms carry the Lewis antigen and are important for interaction with selectins and for functioning. No sulfated O-glycans. Some N-glycosylation. |
| Function | A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. |
| Protein Name | P-Selectin Glycoprotein Ligand 1Psgl-1Selectin P LigandCd Antigen Cd162 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-P-Selectin Glycoprotein Ligand 1 antibodyAnti-Psgl-1 antibodyAnti-Selectin P Ligand antibodyAnti-Cd Antigen Cd162 antibodyAnti-Selplg antibodyAnti-Selp1 antibodyAnti-Selpl antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
