Anti-CD154/CD40L/TNFSF5 antibody [MR1/MR-1] {APC} (STJA0029365)

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STJA0029365
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Host: Rat
Applications: FC
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rat monoclonal antibody anti-Cd40 Ligand is suitable for use in Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : MR1/MR-1
Conjugation: APC
Isotype: IgG1k
Formulation: 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Purification: Purified
Concentration: 0.5 mg/mL
Storage Instruction: Store at 4°C for 12 months. Protect from light. Do not freeze.
Gene Symbol: Cd40lg
Gene ID: 21947
Uniprot ID: CD40L_MOUSE
Post Translational Modifications The soluble form derives from the membrane form by proteolytic processing.
Function Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B. Induces the activation of kinases MAPK8 and PAK2 in T-cells. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. CD40 ligand, soluble form: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3.both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
Protein Name Cd40 Ligand
Cd40-L
T-Cell Antigen Gp39
Tnf-Related Activation Protein
Trap
Tumor Necrosis Factor Ligand Superfamily Member 5
Cd Antigen Cd154 Cleaved Into - Cd40 Ligand - Membrane Form - Cd40 Ligand - Soluble Form
Scd40l
Database Links Reactome: R-MMU-198933
Reactome: -MMU-5668541
Reactome: -MMU-5676594
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Cell Surface
Cd40 Ligand
Soluble Form: Secreted
Release Of Soluble Cd40l From Platelets Is Partially Regulated By Gp Iib/Iiia
Actin Polymerization
And A Matrix Metalloproteinases (Mmp) Inhibitor-Sensitive Pathway
Alternative Antibody Names Anti-Cd40 Ligand antibody
Anti-Cd40-L antibody
Anti-T-Cell Antigen Gp39 antibody
Anti-Tnf-Related Activation Protein antibody
Anti-Trap antibody
Anti-Tumor Necrosis Factor Ligand Superfamily Member 5 antibody
Anti-Cd Antigen Cd154 Cleaved Into - Cd40 Ligand - Membrane Form - Cd40 Ligand - Soluble Form antibody
Anti-Scd40l antibody
Anti-Cd40lg antibody
Anti-Cd40l antibody
Anti-Tnfsf5 antibody

Information sourced from Uniprot.org