Anti-CD15/SSEA-1/Lewis x antibody [SAA1433] (STJA0027769)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2ak
General Information
| Short Description | Mouse monoclonal Alpha (1-3-Fucosyltransferase 4 antibody for use in ELISA, FC and IHC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC/IHC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1433 |
| Isotype | IgG2ak |
| Conjugation | Unconjugated |
| Concentration | 1.32 mg/ml |
| Purification | Protein A/G purified from cell culture supernatant. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | FUT4 |
| Gene ID | 2526 |
| Uniprot ID | FUT4_HUMAN |
Additional Info
| Function | Isoform Short: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE. Isoform Long: Does not generate Lewis X antigens. |
| Protein Name | Alpha-(1 -3-Fucosyltransferase 44-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-FucosyltransferaseElam-1 Ligand FucosyltransferaseFucosyltransferase 4Fucosyltransferase IvFuc-TivFuct-IvGalactoside 3-L-Fucosyltransferase |
| Database Links | Reactome: R-HSA-9037629 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinMembrane-Bound Form In Trans Cisternae Of Golgi |
| Alternative Antibody Names | Anti-Alpha-(1 -3-Fucosyltransferase 4 antibodyAnti-4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase antibodyAnti-Elam-1 Ligand Fucosyltransferase antibodyAnti-Fucosyltransferase 4 antibodyAnti-Fucosyltransferase Iv antibodyAnti-Fuc-Tiv antibodyAnti-Fuct-Iv antibodyAnti-Galactoside 3-L-Fucosyltransferase antibodyAnti-FUT4 antibodyAnti-ELFT antibodyAnti-FCT3A antibody |
Information sourced from Uniprot.org