| Post Translational Modifications | N- and O-glycosylated. Isoform 2: N-glycosylated. |
| Function | Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Has a role in megakaryocytes and platelet formation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration.through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation.through KDR dephosphorylation. Negative regulator of EGFR signaling pathway.through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. Isoform 2: Activates angiogenesis and cell migration. Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase EtaProtein-Tyrosine Phosphatase EtaR-Ptp-EtaDensity-Enhanced Phosphatase 1Dep-1Hptp EtaProtein-Tyrosine Phosphatase Receptor Type JR-Ptp-JCd Antigen Cd148 |
| Database Links | Reactome: R-HSA-202427Reactome: R-HSA-6798695Reactome: R-HSA-6807004Reactome: R-HSA-9706369 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionRuffle MembraneCell JunctionAfter T-Cell StimulationIt Is Temporarily Excluded From Immunological SynapsesIsoform 2: SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase Eta antibodyAnti-Protein-Tyrosine Phosphatase Eta antibodyAnti-R-Ptp-Eta antibodyAnti-Density-Enhanced Phosphatase 1 antibodyAnti-Dep-1 antibodyAnti-Hptp Eta antibodyAnti-Protein-Tyrosine Phosphatase Receptor Type J antibodyAnti-R-Ptp-J antibodyAnti-Cd Antigen Cd148 antibodyAnti-PTPRJ antibodyAnti-DEP1 antibody |
Information sourced from Uniprot.org
