| Tissue Specificity | Expressed in postnatal endothelial cells of the retinal vascular plexus (at protein level). |
| Post Translational Modifications | Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. O-glycosylated. |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Plays a role in coupling actin fibers to cell junctions in endothelial cells, via acting as a cell junctional complex anchor for AMOTL2 and MAGI1. Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Associates with CTNND1/p120-catenin to control CADH5 endocytosis. |
| Protein Name | Cadherin-5Vascular Endothelial CadherinVe-CadherinCd Antigen Cd144 |
| Database Links | Reactome: R-MMU-418990Reactome: -MMU-5218920 |
| Cellular Localisation | Cell JunctionAdherens JunctionCell MembraneSingle-Pass Type I Membrane ProteinCytoplasmFound At Cell-Cell Boundaries And Probably At Cell-Matrix BoundariesKrit1 And Cdh5 Reciprocally Regulate Their Localization To Endothelial Cell-Cell Junctions |
| Alternative Antibody Names | Anti-Cadherin-5 antibodyAnti-Vascular Endothelial Cadherin antibodyAnti-Ve-Cadherin antibodyAnti-Cd Antigen Cd144 antibodyAnti-Cdh5 antibody |
Information sourced from Uniprot.org
