| Tissue Specificity | Expression not restricted to IL6-responsive cells. Found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver. Found in all the cell lines tested except BaF-B03. Expressed paraventricular nucleus of the hypothalamus. |
| Post Translational Modifications | Phosphorylation of Ser-780 down-regulates cell surface expression. Heavily N-glycosylated. Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding. |
| Function | Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop. Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition. |
| Protein Name | Interleukin-6 Receptor Subunit BetaIl-6 Receptor Subunit BetaIl-6r Subunit BetaIl-6r-BetaIl-6rbInterleukin-6 Signal TransducerMembrane Glycoprotein 130Gp130Oncostatin-M Receptor Subunit AlphaCd Antigen Cd130 |
| Database Links | Reactome: R-MMU-1059683Reactome: -MMU-110056Reactome: -MMU-112411Reactome: -MMU-6788467Reactome: -MMU-8984722Reactome: -MMU-9020956 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-6 Receptor Subunit Beta antibodyAnti-Il-6 Receptor Subunit Beta antibodyAnti-Il-6r Subunit Beta antibodyAnti-Il-6r-Beta antibodyAnti-Il-6rb antibodyAnti-Interleukin-6 Signal Transducer antibodyAnti-Membrane Glycoprotein 130 antibodyAnti-Gp130 antibodyAnti-Oncostatin-M Receptor Subunit Alpha antibodyAnti-Cd Antigen Cd130 antibodyAnti-Il6st antibody |
Information sourced from Uniprot.org
