Anti-CD123 antibody IHC Human tonsil STJ180630

Anti-CD123 antibody (26-171) [ZR425] (STJ180630)

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STJ180630
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Short Description :Rabbit monoclonal CD123 (26-171) antibody for use in IHC-P in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC-P
Host:Rabbit
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :ZR425
Isotype:IgG
Conjugation:Unconjugated
Purification:Affinity purified
Dilution Range:1:100-200
Formulation:Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Storage Instruction:Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol:IL3RA
Gene ID:3563
Uniprot ID:IL3RA_HUMAN
Immunogen:Recombinant fragment of human IL3RA protein (around aa 26-171)
Immunogen Region:26-171
Specificity:Positive Control: Lymph node or thymus
Post Translational Modifications Ubiquitinated by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome. Ubiquitinated by RNF128 via 'Lys-27'-linked polyubiquitination, facilitating its degradation through the lysosomal pathway.
Function Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program.
Protein Name Interleukin-3 Receptor Subunit Alpha
Il-3 Receptor Subunit Alpha
Il-3r Subunit Alpha
Il-3r-Alpha
Il-3ra
Cd Antigen Cd123
Database Links Reactome: R-HSA-512988
Reactome: R-HSA-5673001
Reactome: R-HSA-912526
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Interleukin-3 Receptor Subunit Alpha antibody
Anti-Il-3 Receptor Subunit Alpha antibody
Anti-Il-3r Subunit Alpha antibody
Anti-Il-3r-Alpha antibody
Anti-Il-3ra antibody
Anti-Cd Antigen Cd123 antibody
Anti-IL3RA antibody
Anti-IL3R antibody

Information sourced from Uniprot.org

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