| Post Translational Modifications | Ubiquitinated at Lys-357 by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome. Ubiquitinated by RNF128 via 'Lys-27'-linked polyubiquitination, facilitating its degradation through the lysosomal pathway. |
| Function | Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program. |
| Protein Name | Interleukin-3 Receptor Subunit AlphaIl-3 Receptor Subunit AlphaIl-3r Subunit AlphaIl-3r-AlphaIl-3raInterleukin-3 Receptor Class Ii Alpha ChainCd Antigen Cd123 |
| Database Links | |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinExpressed On The Cell SurfaceIsoform 2: Endomembrane SystemMostly Distributed Inside The CellsExcept In The Nuclei And Is Not Transported To The Cell Surface |
| Alternative Antibody Names | Anti-Interleukin-3 Receptor Subunit Alpha antibodyAnti-Il-3 Receptor Subunit Alpha antibodyAnti-Il-3r Subunit Alpha antibodyAnti-Il-3r-Alpha antibodyAnti-Il-3ra antibodyAnti-Interleukin-3 Receptor Class Ii Alpha Chain antibodyAnti-Cd Antigen Cd123 antibodyAnti-Il3ra antibodyAnti-Sut-1 antibody |
Information sourced from Uniprot.org
