| Host: |
Mouse |
| Applications: |
FC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-CD11b is suitable for use in Flow Cytometry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
VIM12 |
| Conjugation: |
PE |
| Isotype: |
IgG1 |
| Formulation: |
PBS with 0.1% sodium azide |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Tissue Specificity | Expressed ubiquitously. Some evidence of isoform-specific tissue distribution. |
| Post Translational Modifications | During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain. Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated. |
| Function | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. |
| Protein Name | Cyclin-Dependent Kinase 11bCell Division Cycle 2-Like Protein Kinase 1Clk-1Cell Division Protein Kinase 11bGalactosyltransferase-Associated Protein Kinase P58/GtaPitslre Serine/Threonine-Protein Kinase Cdc2l1P58 Clk-1 |
| Database Links | Reactome: R-HSA-380270 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 11b antibodyAnti-Cell Division Cycle 2-Like Protein Kinase 1 antibodyAnti-Clk-1 antibodyAnti-Cell Division Protein Kinase 11b antibodyAnti-Galactosyltransferase-Associated Protein Kinase P58/Gta antibodyAnti-Pitslre Serine/Threonine-Protein Kinase Cdc2l1 antibodyAnti-P58 Clk-1 antibodyAnti-CDK11B antibodyAnti-CDC2L1 antibodyAnti-CDK11 antibodyAnti-PITSLREA antibodyAnti-PK58 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Mouse bone marrow cells were stained with Anti-Mouse/Human CD11b antibody (STJA0000431) [Used at 0.02 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained bone marrow cells (blank black histogram) were used as control.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/145284/291948/STJA0000431_1__85787.1631205751.jpg?c=1 "Mouse bone marrow cells were stained with Anti-Mouse/Human CD11b antibody (STJA0000431) [Used at 0.02 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained bone marrow cells (blank black histogram) were used as control.")
