Anti-CD11a/ITGAL nanobody [SAA1305] (STJN000169)

Anti-CD11a/ITGAL nanobody [SAA1305] (STJN000169)

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STJN000169
£378.50 - £1,632.50
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Integrin Alpha-L is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1305
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: ITGAL
Gene ID: 3683
Uniprot ID: ITAL_HUMAN
Post Translational Modifications In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
Function Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Acts as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Protein Name Integrin Alpha-L
Cd11 Antigen-Like Family Member A
Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain
Lfa-1a
Leukocyte Function-Associated Molecule 1 Alpha Chain
Cd Antigen Cd11a
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-6798695
Reactome: R-HSA-8949275
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Upon Antigen Recognition By The Tcr
Is Recruited To Lipid Rafts
Alternative Nanobody Names Anti-Integrin Alpha-L nanobody
Anti-Cd11 Antigen-Like Family Member A nanobody
Anti-Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain nanobody
Anti-Lfa-1a nanobody
Anti-Leukocyte Function-Associated Molecule 1 Alpha Chain nanobody
Anti-Cd Antigen Cd11a nanobody
Anti-ITGAL nanobody
Anti-CD11A nanobody

Information sourced from Uniprot.org

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