Host: |
Rat |
Applications: |
FC |
Reactivity: |
Mouse |
Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Short Description: |
Rat monoclonal antibody anti-Integrin alpha-L is suitable for use in Flow Cytometry research applications. |
Clonality: |
Monoclonal |
Clone ID: |
FD441.8 |
Conjugation: |
AF488 |
Isotype: |
IgG2bk |
Formulation: |
PBS with 0.05% Proclin300, 1% BSA |
Storage Instruction: |
Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Tissue Specificity | Leukocytes. |
Post Translational Modifications | In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for the activation by some physiological agents. |
Function | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. |
Protein Name | Integrin Alpha-LCd11 Antigen-Like Family Member ALeukocyte Adhesion Glycoprotein Lfa-1 Alpha ChainLfa-1aLeukocyte Function-Associated Molecule 1 Alpha ChainLymphocyte Antigen 15Ly-15Cd Antigen Cd11a |
Database Links | Reactome: R-MMU-198933Reactome: -MMU-202733Reactome: -MMU-216083Reactome: -MMU-6798695 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Integrin Alpha-L antibodyAnti-Cd11 Antigen-Like Family Member A antibodyAnti-Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain antibodyAnti-Lfa-1a antibodyAnti-Leukocyte Function-Associated Molecule 1 Alpha Chain antibodyAnti-Lymphocyte Antigen 15 antibodyAnti-Ly-15 antibodyAnti-Cd Antigen Cd11a antibodyAnti-Itgal antibodyAnti-Lfa-1 antibodyAnti-Ly-15 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance