| Function | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). |
| Protein Name | Nectin-2Herpes Virus Entry Mediator BHerpesvirus Entry Mediator BHvebNectin Cell Adhesion Molecule 2Poliovirus Receptor-Related Protein 2Cd Antigen Cd112 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-418990Reactome: R-HSA-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Nanobody Names | Anti-Nectin-2 nanobodyAnti-Herpes Virus Entry Mediator B nanobodyAnti-Herpesvirus Entry Mediator B nanobodyAnti-Hveb nanobodyAnti-Nectin Cell Adhesion Molecule 2 nanobodyAnti-Poliovirus Receptor-Related Protein 2 nanobodyAnti-Cd Antigen Cd112 nanobodyAnti-NECTIN2 nanobodyAnti-HVEB nanobodyAnti-PRR2 nanobodyAnti-PVRL2 nanobody |
Information sourced from Uniprot.org
