Anti-CD105 antibody [SM4908] (STJA0004908)

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STJA0004908
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Short Description :Mouse monoclonal anti-CD105 for use in WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB
Host:Mouse
Reactivity:Mouse
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SM4908
Isotype:IgG
Conjugation:Unconjugated
Purification:Affinity purification
Dilution Range:WB (M) 1:500-1:1000
Formulation:PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol.
Storage Instruction:Store at-20C for up to one year, and avoid repeated freeze-thaw cycles.
Gene Symbol:Eng
Gene ID:13805
Uniprot ID:EGLN_MOUSE
Immunogen:Recombinant protein corresponding to Mouse CD105
Function Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. May play a role in the binding of endothelial cells to integrins. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3.
Protein Name Endoglin
Cell Surface Mj7/18 Antigen
Cd Antigen Cd105
Database Links
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Endoglin antibody
Anti-Cell Surface Mj7/18 Antigen antibody
Anti-Cd Antigen Cd105 antibody
Anti-Eng antibody
Anti-Edg antibody

Information sourced from Uniprot.org