| Background | Cluster of Differentiation 10 (CD10) is a cell surface metalloendopeptidase that cleaves and inactivates several peptide hormones including glucagon, enkephalins, and oxytocin. Also known as Common Acute Lymphoblastic Leukemia Antigen (CALLA) , it is an important cell surface marker in the diagnosis of human ALL (Acute Lymphocytic Leukemia) , and is found positive in precursor B lymphoblastic leukemia/lymphoma, angioimmunoblastic T-cell lymphoma, Burkitt s lymphoma, and follicular germinal center lymphoma. CD10 expression has also been reported in a variety of non-hematolymphoid tissues, particularly of the kidney. It is a useful aid in the diagnosis of various malignant tumours such as renal cell carcinoma, endometrial stromal sarcoma, and hepatocellular carcinoma. |
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