Anti-CD10 antibody (52-750) [S5672RM] (STJ11105672)

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STJ11105672
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Host: Rabbit
Applications: WB/FC/ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S5672RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:1000-1:5000
FC:1:500-1:1000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Mme
Gene ID: 17380
Uniprot ID: NEP_MOUSE
Immunogen Region: 52-750
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 52-750 of mouse CD10 (NP_032630.2).
Immunogen Sequence: YDDGICKSSDCIKSAARLIQ NMDASVEPCTDFFKYACGGW LKRNVIPETSSRYSNFDILR DELEVILKDVLQEPKTEDIV AVQKAKTLYRSCINESAIDS RGGQPLLKLLPDIYGWPVAS DNWDQTYGTSWTAEKSIAQL NSKYGKKVLINFFVGTDDKN STQHIIHFDQPRLGLPSRDY YECTGIYKEACTAYVDFMIS VARLIRQEQSLPIDENQLSL EMNKVMELEKEIANATTKP
Post Translational Modifications Myristoylation is a determinant of membrane targeting. Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
Function Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Catalyzes cleavage of bradykinin, substance P and neurotensin peptides. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of the atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
Protein Name Neprilysin
Atriopeptidase
Enkephalinase
Neutral Endopeptidase 24.11
Nep
Neutral Endopeptidase
Skin Fibroblast Elastase
Sfe
Cd Antigen Cd10
Database Links Reactome: R-MMU-2022377
Reactome: -MMU-5578768
Reactome: -MMU-6798695
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Antibody Names Anti-Neprilysin antibody
Anti-Atriopeptidase antibody
Anti-Enkephalinase antibody
Anti-Neutral Endopeptidase 24.11 antibody
Anti-Nep antibody
Anti-Neutral Endopeptidase antibody
Anti-Skin Fibroblast Elastase antibody
Anti-Sfe antibody
Anti-Cd Antigen Cd10 antibody
Anti-Mme antibody

Information sourced from Uniprot.org