| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-C-C chemokine receptor type 5 (151-200 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-P 1:500-200 ELISA 1:10000-20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCR5 |
| Gene ID: | 1234 |
| Uniprot ID: | CCR5_HUMAN |
| Immunogen Region: | 151-200 aa |
| Specificity: | The antibody detects endogenous CKR-5 |
| Immunogen: | Synthetic peptide from the human protein at the amino acid range 151-200 |
| Post Translational Modifications | Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4. O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site even if Ser-7 may be also O-glycosylated. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen. Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry. Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES. |
| Function | Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1. |
| Protein Name | C-C Chemokine Receptor Type 5 C-C Ckr-5 Cc-Ckr-5 Ccr-5 Ccr5 Chemr13 Hiv-1 Fusion Coreceptor Cd Antigen Cd195 |
| Database Links | Reactome: R-HSA-173107 Reactome: R-HSA-380108 Reactome: R-HSA-418594 Reactome: R-HSA-6783783 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-C-C Chemokine Receptor Type 5 antibody Anti-C-C Ckr-5 antibody Anti-Cc-Ckr-5 antibody Anti-Ccr-5 antibody Anti-Ccr5 antibody Anti-Chemr13 antibody Anti-Hiv-1 Fusion Coreceptor antibody Anti-Cd Antigen Cd195 antibody Anti-CCR5 antibody Anti-CMKBR5 antibody |
Information sourced from Uniprot.org