Anti-CCR4 antibody (211-260 aa) (STJ92300)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CCR4 at the amino acid range 211-260
General Information
| Short Description | Rabbit polyclonal anti-C-C chemokine receptor type 4 (211-260 aa) for use in IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IF 1:200-1:1000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CCR4 |
| Gene ID | 1233 |
| Uniprot ID | CCR4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CCR4 at the amino acid range 211-260 |
| Immunogen Region | 211-260 aa |
| Specificity | CKR-4 Polyclonal Antibody detects endogenous levels of CKR-4 protein. |
Additional Info
| Post Translational Modifications | In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2. |
| Function | High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. |
| Protein Name | C-C Chemokine Receptor Type 4C-C Ckr-4Cc-Ckr-4Ccr-4Ccr4K5-5Cd Antigen Cd194 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-C-C Chemokine Receptor Type 4 antibodyAnti-C-C Ckr-4 antibodyAnti-Cc-Ckr-4 antibodyAnti-Ccr-4 antibodyAnti-Ccr4 antibodyAnti-K5-5 antibodyAnti-Cd Antigen Cd194 antibodyAnti-CCR4 antibodyAnti-CMKBR4 antibody |
Information sourced from Uniprot.org