| Host: |
Rabbit |
| Applications: |
WB/IHC-P/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCR1 |
| Gene ID: |
1230 |
| Uniprot ID: |
CCR1_HUMAN |
| Immunogen Region: |
255-354 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 255-354 of human CCR1 (NP_001286.1). |
| Immunogen Sequence: |
YNLTILISVFQDFLFTHECE QSRHLDLAVQVTEVIAYTHC CVNPVIYAFVGERFRKYLRQ LFHRRVAVHLVKWLPFLSVD RLERVSSTSPSTGEHELSAG |
| Tissue Specificity | Widely expressed in different hematopoietic cells. |
| Function | Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF-alpha and leukotriene B4. Mediates also monocyte migration upon CXCL4 binding. Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway. |
| Protein Name | C-C Chemokine Receptor Type 1C-C Ckr-1Cc-Ckr-1Ccr-1Ccr1Hm145Ld78 ReceptorMacrophage Inflammatory Protein 1-Alpha ReceptorMip-1alpha-RRantes-RCd Antigen Cd191 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6783783 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-C-C Chemokine Receptor Type 1 antibodyAnti-C-C Ckr-1 antibodyAnti-Cc-Ckr-1 antibodyAnti-Ccr-1 antibodyAnti-Ccr1 antibodyAnti-Hm145 antibodyAnti-Ld78 Receptor antibodyAnti-Macrophage Inflammatory Protein 1-Alpha Receptor antibodyAnti-Mip-1alpha-R antibodyAnti-Rantes-R antibodyAnti-Cd Antigen Cd191 antibodyAnti-CCR1 antibodyAnti-CMKBR1 antibodyAnti-CMKR1 antibodyAnti-SCYAR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
