| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CCP110 |
| Gene ID: |
9738 |
| Uniprot ID: |
CP110_HUMAN |
| Immunogen Region: |
1-280 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human CCP110 (NP_055526.3). |
| Immunogen Sequence: |
MEEYEKFCEKSLARIQEASL STESFLPAQSESISLIRFHG VAILSPLLNIEKRKEMQQEK QKALDVEARKQVNRKKALLT RVQEILDNVQVRKAPNASDF DQWEMETVYSNSEVRNLNVP ATFPNSFPSHTEHSTAAKLD KIAGILPLDNEDQCKTDGID LARDSEGFNSPKQCDSSNIS HVENEAFPKTSSATPQETLI SDGPFSVNEQQDLPLLAEVI PDPYVMSLQNLMKKSKEYI |
| Tissue Specificity | Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. |
| Post Translational Modifications | Phosphorylated by CDKs. Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Ubiquitinated by the EDVP complex, leading to its degradation. |
| Function | Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. |
| Protein Name | Centriolar Coiled-Coil Protein Of 110 KdaCentrosomal Protein Of 110 KdaCp110Cep110 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-5689880Reactome: R-HSA-8854518Reactome: R-HSA-9013424 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleCilium Basal BodyRecruited Early And Then Associates With The Growing Distal TipsRecruited To The Mother Centriole By Kif24Removed From Centrioles By Ttbk2Leading To Initiation Of Ciliogenesis And Localizes Only To The Daughter Centriole In Ciliated CellsIn Cytotoxic T Lymphocytes Remains Associated With The Mother Centriole During Docking Of The Centrosome At The Immunological Synapse Upon Target ContactRecruited At The Distal End Of The Mother Centriole By Mphosph9 |
| Alternative Antibody Names | Anti-Centriolar Coiled-Coil Protein Of 110 Kda antibodyAnti-Centrosomal Protein Of 110 Kda antibodyAnti-Cp110 antibodyAnti-Cep110 antibodyAnti-CCP110 antibodyAnti-CEP110 antibodyAnti-CP110 antibodyAnti-KIAA0419 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
