| Function | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). The activity of this complex is regulated by binding with 7SK snRNA. Plays a role during muscle differentiation.P-TEFB complex interacts with MYOD1.this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes.this event correlates with hyperphosphorylation of the CTD domain of RNA pol II. In addition, enhances MYOD1-dependent transcription through interaction with PKN1. Involved in early embryo development. (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters. |
| Protein Name | Cyclin-T2Cyct2 |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-167152Reactome: R-HSA-167287Reactome: R-HSA-167290Reactome: R-HSA-2173796Reactome: R-HSA-674695Reactome: R-HSA-6796648Reactome: R-HSA-6807505Reactome: R-HSA-75955 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusNucleus In Differentiating Cells |
| Alternative Antibody Names | Anti-Cyclin-T2 antibodyAnti-Cyct2 antibodyAnti-CCNT2 antibody |
Information sourced from Uniprot.org
