| Post Translational Modifications | N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes. |
| Function | Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. |
| Protein Name | C-C Motif Chemokine 4G-26 T-Lymphocyte-Secreted ProteinHc21Lymphocyte Activation Gene 1 ProteinLag-1Mip-1-Beta(1-69Macrophage Inflammatory Protein 1-BetaMip-1-BetaPat 744Protein H400Sis-GammaSmall-Inducible Cytokine A4T-Cell Activation Protein 2Act-2 Cleaved Into - Mip-1-Beta(3-69 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6783783 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-C-C Motif Chemokine 4 antibodyAnti-G-26 T-Lymphocyte-Secreted Protein antibodyAnti-Hc21 antibodyAnti-Lymphocyte Activation Gene 1 Protein antibodyAnti-Lag-1 antibodyAnti-Mip-1-Beta(1-69 antibodyAnti-Macrophage Inflammatory Protein 1-Beta antibodyAnti-Mip-1-Beta antibodyAnti-Pat 744 antibodyAnti-Protein H400 antibodyAnti-Sis-Gamma antibodyAnti-Small-Inducible Cytokine A4 antibodyAnti-T-Cell Activation Protein 2 antibodyAnti-Act-2 Cleaved Into - Mip-1-Beta(3-69 antibodyAnti-CCL4 antibodyAnti-LAG1 antibodyAnti-MIP1B antibodyAnti-SCYA4 antibody |
Information sourced from Uniprot.org
