| Post Translational Modifications | Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. N-Glycosylated. |
| Function | Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. |
| Protein Name | C-C Motif Chemokine 2Hc11Monocyte Chemoattractant Protein 1Monocyte Chemotactic And Activating FactorMcafMonocyte Chemotactic Protein 1Mcp-1Monocyte Secretory Protein JeSmall-Inducible Cytokine A2 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-380994Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-9818026 |
| Cellular Localisation | Secreted |
| Alternative Nanobody Names | Anti-C-C Motif Chemokine 2 nanobodyAnti-Hc11 nanobodyAnti-Monocyte Chemoattractant Protein 1 nanobodyAnti-Monocyte Chemotactic And Activating Factor nanobodyAnti-Mcaf nanobodyAnti-Monocyte Chemotactic Protein 1 nanobodyAnti-Mcp-1 nanobodyAnti-Monocyte Secretory Protein Je nanobodyAnti-Small-Inducible Cytokine A2 nanobodyAnti-CCL2 nanobodyAnti-MCP1 nanobodyAnti-SCYA2 nanobody |
Information sourced from Uniprot.org
![Anti-CCL2/MCP-1 nanobody [SAA1269] (STJN000140)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200753/412935/STJN000140-SDS-PAGE-1__77181.1749232467.jpg?c=1 "Anti-CCL2/MCP-1 nanobody [SAA1269] (STJN000140)")
![Anti-CCL2/MCP-1 nanobody [SAA1269] (STJN000140)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200753/412935/STJN000140-SDS-PAGE-1__77181.1749232467.jpg?c=1 "Anti-CCL2/MCP-1 nanobody [SAA1269] (STJN000140)")
