Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Rat/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Gastrin/cholecystokinin type B receptor (306-356 aa) is suitable for use in Western Blot research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:1000-2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CCKBR |
Gene ID: | 887 |
Uniprot ID: | GASR_HUMAN |
Immunogen Region: | 306-356 aa |
Specificity: | CCKBR protein (A214) detects endogenous levels of CCKBR |
Immunogen: | Synthetic peptide derived from CCKBR at the amino acid range 306-356 |
Function | Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism. |
Protein Name | Gastrin/Cholecystokinin Type B ReceptorCck-B ReceptorCck-BrCholecystokinin-2 ReceptorCck2-R |
Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-881907 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
Alternative Antibody Names | Anti-Gastrin/Cholecystokinin Type B Receptor antibodyAnti-Cck-B Receptor antibodyAnti-Cck-Br antibodyAnti-Cholecystokinin-2 Receptor antibodyAnti-Cck2-R antibodyAnti-CCKBR antibodyAnti-CCKRB antibody |
Information sourced from Uniprot.org