Anti-CCDC61 antibody (352-531) (STJ112379)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CCDC61 (352-531) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CCDC61 |
| Gene ID | 729440 |
| Uniprot ID | CCD61_HUMAN |
| Immunogen Region | 352-531 |
| Immunogen Sequence | PSPSPTGGRALRFDPTAFVK AKERKQREIQMKQQQRNRLG SGGSGDGPSVSWSRQTQPPA ALTGRGDAPNRSRNRSSSVD SFRSRCSSASSCSDLEDFSE SLSRGGHRRRGKPPSPTPWS GSNMKSPPVERSHHQKSLAN SGGWVPIKEYSSEHQAADMA EIDARLKALQEYMNRLDMRS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 352-531 of human CCDC61 (NP_001073871.1). |
Additional Info
| Function | Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker. In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning. During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure. Has been proposed to play a role in CEP170 recruitment to centrosomes. However, this function could not be confirmed. Plays a non-essential role in ciliogenesis. |
| Protein Name | Centrosomal Protein Ccdc61Coiled-Coil Domain-Containing Protein 61Vfl3 Homolog |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentriolar SatelliteCilium Basal BodyLocalization At The Centriolar Satellite Is Dependent On Intact Microtubule NetworkLocalizes At The Centriole Subdistal Appendages And Proximal EndsLocalized To Centrosomal/Satellite-Like Structures With The Onset Of Centrosome Separation In Early G2 |
| Alternative Antibody Names | Anti-Centrosomal Protein Ccdc61 antibodyAnti-Coiled-Coil Domain-Containing Protein 61 antibodyAnti-Vfl3 Homolog antibodyAnti-CCDC61 antibody |
Information sourced from Uniprot.org