| Short Description : | Rabbit polyclonal anti-Mitochondrial potassium channel (357-407 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCDC51 |
| Gene ID: | 79714 |
| Uniprot ID: | MITOK_HUMAN |
| Immunogen: | Synthesized peptide derived from the human CCD51 at the amino acid range 357-407 |
| Immunogen Region: | 357-407 aa |
| Specificity: | This antibody detects endogenous levels of CCD51 at Human/Mouse/Rat |
| Function | Pore-forming subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with ATP-binding subunit ABCB8/MITOSUR of the mitoK(ATP) channel, mediates ATP-dependent K(+) currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume. |
| Protein Name | Mitochondrial Potassium ChannelMitokCoiled-Coil Domain-Containing Protein 51 |
| Database Links | |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane ProteinIsoform 1: Mitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-Mitochondrial Potassium Channel antibodyAnti-Mitok antibodyAnti-Coiled-Coil Domain-Containing Protein 51 antibodyAnti-CCDC51 antibodyAnti-MITOK antibody |
Information sourced from Uniprot.org
