| Host: |
Rabbit |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Gene Symbol: |
CBX7 |
| Gene ID: |
23492 |
| Uniprot ID: |
CBX7_HUMAN |
| Immunogen Region: |
1-110 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human CBX7 (NP_783640.1). |
| Immunogen Sequence: |
MELSAIGEQVFAVESIRKKR VRKGKVEYLVKWKGWPPKYS TWEPEEHILDPRLVMAYEEK EERDRASGYRKRGPKPKRLL LQRLYSMDLRSSHKAKGKEK LCFSLTCPLG |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. |
| Protein Name | Chromobox Protein Homolog 7 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Chromobox Protein Homolog 7 antibodyAnti-CBX7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
