| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Chromobox protein homolog 3 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CBX3 |
| Gene ID: | 11335 |
| Uniprot ID: | CBX3_HUMAN |
| Specificity: | This antibody detects endogenous levels of HP1 gamma/CBX3 (citrulline R108) at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human HP1 gamma/CBX3 (citrulline R108) |
| Post Translational Modifications | Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. |
| Function | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs). |
| Protein Name | Chromobox Protein Homolog 3 Hech Heterochromatin Protein 1 Homolog Gamma Hp1 Gamma Modifier 2 Protein |
| Database Links | Reactome: R-HSA-427389 Reactome: R-HSA-73772 Reactome: R-HSA-8953750 |
| Cellular Localisation | Nucleus Associates With Euchromatin And Is Largely Excluded From Constitutive Heterochromatin May Be Associated With Microtubules And Mitotic Poles During Mitosis (Potential) |
| Alternative Antibody Names | Anti-Chromobox Protein Homolog 3 antibody Anti-Hech antibody Anti-Heterochromatin Protein 1 Homolog Gamma antibody Anti-Hp1 Gamma antibody Anti-Modifier 2 Protein antibody Anti-CBX3 antibody |
Information sourced from Uniprot.org