• Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using HP1 gamma Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from 293 cells, using HP1 gamma Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of HEPG2 cells using HP1 Gamma Polyclonal Antibody diluted at 1：500 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-CBX3 antibody (59-108 aa) (STJ93589)

SKU:
STJ93589

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Chromobox protein homolog 3 (59-108 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CBX3
Gene ID: 11335
Uniprot ID: CBX3_HUMAN
Immunogen Region: 59-108 aa
Specificity: HP1 Gamma Polyclonal Antibody detects endogenous levels of HP1 Gamma protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human HP1 gamma at the amino acid range 59-108
Function Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs).
Protein Name Chromobox Protein Homolog 3
Hech
Heterochromatin Protein 1 Homolog Gamma
Hp1 Gamma
Modifier 2 Protein
Database Links Reactome: R-HSA-427389
Reactome: R-HSA-73772
Reactome: R-HSA-8953750
Cellular Localisation Nucleus
Associates With Euchromatin And Is Largely Excluded From Constitutive Heterochromatin
May Be Associated With Microtubules And Mitotic Poles During Mitosis (Potential)
Alternative Antibody Names Anti-Chromobox Protein Homolog 3 antibody
Anti-Hech antibody
Anti-Heterochromatin Protein 1 Homolog Gamma antibody
Anti-Hp1 Gamma antibody
Anti-Modifier 2 Protein antibody
Anti-CBX3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance