• Immunohistochemistry analysis of paraffin-embedded Human lung cancer using HP1 gamma antibody. High-pressure and temperature Sodium Citrate pH 6. 0 was used for antigen retrieval.
  • Western blot analysis of HP1 gamma/CBX3 in Jurkat lysates using HP1 gamma antibody.

Anti-CBX3 antibody (54-67 aa) [R06-6A0] (STJA0011450)

SKU:
STJA0011450-100

£264.50
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Host: Rabbit
Applications: WB/IHC-P/IP
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-HP1 gamma (54-67 aa) is suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation research applications.
Clonality: Monoclonal
Clone ID: R06-6A0
Conjugation: Unconjugated
Isotype: IgG
Formulation: 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Purification: Affinity Purified
Concentration: 0.3 mg/ml
Dilution Range: WB 1:500-1:1000
IHC 1:50-1:100
IP 1:20
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: CBX3
Gene ID: 11335
Uniprot ID: CBX3_HUMAN
Immunogen Region: 54-67 aa
Immunogen: A synthetic peptide of human HP1 gamma
Post Translational Modifications Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
Function Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs).
Protein Name Chromobox Protein Homolog 3
Hech
Heterochromatin Protein 1 Homolog Gamma
Hp1 Gamma
Modifier 2 Protein
Database Links Reactome: R-HSA-427389
Reactome: R-HSA-73772
Reactome: R-HSA-8953750
Cellular Localisation Nucleus
Associates With Euchromatin And Is Largely Excluded From Constitutive Heterochromatin
May Be Associated With Microtubules And Mitotic Poles During Mitosis (Potential)
Alternative Antibody Names Anti-Chromobox Protein Homolog 3 antibody
Anti-Hech antibody
Anti-Heterochromatin Protein 1 Homolog Gamma antibody
Anti-Hp1 Gamma antibody
Anti-Modifier 2 Protein antibody
Anti-CBX3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance