Anti-CBR4 antibody (1-237) (STJ27063)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CBR4 (1-237) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CBR4 |
| Gene ID | 84869 |
| Uniprot ID | CBR4_HUMAN |
| Immunogen Region | 1-237 |
| Immunogen Sequence | MDKVCAVFGGSRGIGRAVAQ LMARKGYRLAVIARNLEGAK AAAGDLGGDHLAFSCDVAKE HDVQNTFEELEKHLGRVNFL VNAAGINRDGLLVRTKTEDM VSQLHTNLLGSMLTCKAAMR TMIQQQGGSIVNVGSIVGLK GNSGQSVYSASKGGLVGFSR ALAKEVARKKIRVNVVAPGF VHTDMTKDLKEEHLKKNIPL GRFGETIEVAHAVVFLLESP YITGHVLVVDGGLQLIL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human CBR4 (NP_116172.2). |
Additional Info
| Tissue Specificity | Detected in liver and kidney (at protein level). Displays the highest expression in neuronal and muscle tissues. |
| Function | Component of the heterotetramer complex KAR (3-ketoacyl-acyl carrier protein reductase or 3-ketoacyl-ACP reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-ACP to (3R)-hydroxyacyl-ACP in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). |
| Protein Name | 3-Oxoacyl-Acyl-Carrier-Protein Reductase3-Ketoacyl-Acyl-Carrier-Protein Reductase Beta SubunitKar Beta SubunitCarbonyl Reductase Family Member 4Cbr4Quinone Reductase Cbr4Short Chain Dehydrogenase/Reductase Family 45c Member 1 |
| Database Links | Reactome: R-HSA-75105 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-3-Oxoacyl-Acyl-Carrier-Protein Reductase antibodyAnti-3-Ketoacyl-Acyl-Carrier-Protein Reductase Beta Subunit antibodyAnti-Kar Beta Subunit antibodyAnti-Carbonyl Reductase Family Member 4 antibodyAnti-Cbr4 antibodyAnti-Quinone Reductase Cbr4 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 45c Member 1 antibodyAnti-CBR4 antibodyAnti-SDR45C1 antibody |
Information sourced from Uniprot.org