Anti-CAVIN1 nanobody [SAA2295] (STJN000681)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-His
General Information
| Short Description | Alpaca monoclonal nanobody anti-CAVIN1 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA2295 |
| Isotype | VHH-His |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Purified by Nickel column. |
| Dilution Range | ELISA: 1:2000-1:20000 |
| Formulation | 0.01M PBS pH 7.4 |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact with the lab for this information. |
Target Information
| Gene Symbol | CAVIN1 |
| Gene ID | 284119 |
| Uniprot ID | CAVN1_HUMAN |
Additional Info
| Function | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template. The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A. |
| Protein Name | Caveolae-Associated Protein 1Cavin-1Polymerase I And Transcript Release Factor |
| Database Links | Reactome: R-HSA-73863Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
| Cellular Localisation | MembraneCaveolaCell MembraneMicrosomeEndoplasmic ReticulumCytoplasmCytosolMitochondrionNucleusTranslocates To The Cytoplasm From The Caveolae Upon Insulin StimulationColocalizes With Cav1 In Lipid Rafts In AdipocytesLocalizes In The Caveolae In A Caveolin-Dependent Manner |
| Alternative Nanobody Names | Anti-Caveolae-Associated Protein 1 nanobodyAnti-Cavin-1 nanobodyAnti-Polymerase I And Transcript Release Factor nanobodyAnti-CAVIN1 nanobodyAnti-PTRF nanobodyAnti-FKSG13 nanobody |
Information sourced from Uniprot.org