| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Caveolae-associated protein 1 (90-170 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAVIN1 |
| Gene ID: | 284119 |
| Uniprot ID: | CAVN1_HUMAN |
| Immunogen Region: | 90-170 aa |
| Specificity: | PTRF Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 90-170 |
| Function | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template. The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A. |
| Protein Name | Caveolae-Associated Protein 1 Cavin-1 Polymerase I And Transcript Release Factor |
| Database Links | Reactome: R-HSA-73863 Reactome: R-HSA-8980692 Reactome: R-HSA-9013026 Reactome: R-HSA-9013106 |
| Cellular Localisation | Membrane Caveola Cell Membrane Microsome Endoplasmic Reticulum Cytoplasm Cytosol Mitochondrion Nucleus Translocates To The Cytoplasm From The Caveolae Upon Insulin Stimulation Colocalizes With Cav1 In Lipid Rafts In Adipocytes Localizes In The Caveolae In A Caveolin-Dependent Manner |
| Alternative Antibody Names | Anti-Caveolae-Associated Protein 1 antibody Anti-Cavin-1 antibody Anti-Polymerase I And Transcript Release Factor antibody Anti-CAVIN1 antibody Anti-PTRF antibody Anti-FKSG13 antibody |
Information sourced from Uniprot.org