| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CASR (180-536) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CASR |
| Gene ID: |
846 |
| Uniprot ID: |
CASR_HUMAN |
| Immunogen Region: |
180-536 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 180-536 of human CASR (NP_000379.3). |
| Immunogen Sequence: |
FKSFLRTIPNDEHQATAMAD IIEYFRWNWVGTIAADDDYG RPGIEKFREEAEERDICIDF SELISQYSDEEEIQHVVEVI QNSTAKVIVVFSSGPDLEPL IKEIVRRNITGKIWLASEAW ASSSLIAMPQYFHVVGGTIG FALKAGQIPGFREFLKKVHP RKSVHNGFAKEFWEETFNCH LQEGAKGPLPVDTFLRGHEE SGDRFSNSSTAFRPLCTGDE NISSVETPYIDYTHLRISY |
| Tissue Specificity | Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta. |
| Post Translational Modifications | N-glycosylated. Ubiquitinated by RNF19A.which induces proteasomal degradation. |
| Function | G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation. |
| Protein Name | Extracellular Calcium-Sensing ReceptorCarCasrHcasrParathyroid Cell Calcium-Sensing Receptor 1Pcar1 |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-418594Reactome: R-HSA-420499 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Extracellular Calcium-Sensing Receptor antibodyAnti-Car antibodyAnti-Casr antibodyAnti-Hcasr antibodyAnti-Parathyroid Cell Calcium-Sensing Receptor 1 antibodyAnti-Pcar1 antibodyAnti-CASR antibodyAnti-GPRC2A antibodyAnti-PCAR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
