| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Calsequestrin-1 (322-372 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CASQ1 |
| Gene ID: |
844 |
| Uniprot ID: |
CASQ1_HUMAN |
| Immunogen Region: |
322-372 aa |
| Specificity: |
This antibody detects endogenous levels of CASQ1 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human CASQ1 at the amino acid range 322-372 |
| Post Translational Modifications | N-glycosylated. |
| Function | Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1.this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity. |
| Protein Name | Calsequestrin-1CalmitineCalsequestrin - Skeletal Muscle Isoform |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775 |
| Cellular Localisation | Endoplasmic ReticulumSarcoplasmic ReticulumSarcoplasmic Reticulum LumenSarcoplasmic Reticulum MembranePeripheral Membrane ProteinLumenal SideMitochondrion MatrixThis Isoform Of Calsequestrin Occurs In The Sarcoplasmic Reticulum's Terminal Cisternae Luminal Spaces Of Fast Skeletal Muscle CellsPreferentially Forms Linear And Round Aggregates In The Endoplasmic Reticulum (Er) Of Resting CellsIn A Minority Of CellsHomogeneously Detected In The Er LumenColocalizes With Stim1 At Endoplasmic Reticulum In Response To A Depletion Of Intracellular Calcium |
| Alternative Antibody Names | Anti-Calsequestrin-1 antibodyAnti-Calmitine antibodyAnti-Calsequestrin - Skeletal Muscle Isoform antibodyAnti-CASQ1 antibodyAnti-CASQ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
