| Post Translational Modifications | N-glycosylated. |
| Function | Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1.this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity. |
| Protein Name | Calsequestrin-1CalmitineCalsequestrin - Skeletal Muscle Isoform |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775 |
| Cellular Localisation | Endoplasmic ReticulumSarcoplasmic ReticulumSarcoplasmic Reticulum LumenSarcoplasmic Reticulum MembranePeripheral Membrane ProteinLumenal SideMitochondrion MatrixThis Isoform Of Calsequestrin Occurs In The Sarcoplasmic Reticulum's Terminal Cisternae Luminal Spaces Of Fast Skeletal Muscle CellsPreferentially Forms Linear And Round Aggregates In The Endoplasmic Reticulum (Er) Of Resting CellsIn A Minority Of CellsHomogeneously Detected In The Er LumenColocalizes With Stim1 At Endoplasmic Reticulum In Response To A Depletion Of Intracellular Calcium |
| Alternative Antibody Names | Anti-Calsequestrin-1 antibodyAnti-Calmitine antibodyAnti-Calsequestrin - Skeletal Muscle Isoform antibodyAnti-CASQ1 antibodyAnti-CASQ antibody |
Information sourced from Uniprot.org
