| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CASK |
| Gene ID: | 8573 |
| Uniprot ID: | CSKP_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CASK (NP_001119526.1). |
| Immunogen Sequence: | MADDDVLFEDVYELCEVIGK GPFSVVRRCINRETGQQFAV KIVDVAKFTSSPGLSTEDLK REASICHMLKHPHIVELLET YSSDGMLYMVFEFMDGADLC FEIVKRADAGFVYSEAVASH YMRQILEALRYCHDNNIIHR DVKPHCVLLASKENSAPVKL GGFGVAIQLGESGLVAGGRV GTPHFMAPEVVKREPYGKPV DVWGCGVILFILLSGCLPFY GTKERLFEGIIKGKYKMNP |
| Tissue Specificity | Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver. |
| Function | Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. |
| Protein Name | Peripheral Plasma Membrane Protein CaskHcaskCalcium/Calmodulin-Dependent Serine Protein KinaseProtein Lin-2 Homolog |
| Database Links | Reactome: R-HSA-212676Reactome: R-HSA-3000170Reactome: R-HSA-373753Reactome: R-HSA-6794361Reactome: R-HSA-9609736Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | NucleusCytoplasmCell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Peripheral Plasma Membrane Protein Cask antibodyAnti-Hcask antibodyAnti-Calcium/Calmodulin-Dependent Serine Protein Kinase antibodyAnti-Protein Lin-2 Homolog antibodyAnti-CASK antibodyAnti-LIN2 antibody |
Information sourced from Uniprot.org
