| Host: | Rabbit |
| Applications: | WB/IHC-F/IHC-P/ICC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-Casein Kinase 2 beta for use in WB, IHC-F, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | R01-5D5 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Purification: | Affinity Purified |
| Concentration: | 0.3 mg/mL |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | CSNK2B |
| Gene ID: | 1460 |
| Uniprot ID: | CSK2B_HUMAN |
| Immunogen: | A synthetic peptide of human Casein Kinase 2 beta |
| Post Translational Modifications | Phosphorylated by alpha subunit. |
| Function | Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling. (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML. Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcrition. |
| Protein Name | Casein Kinase Ii Subunit BetaCk Ii BetaPhosvitinProtein G5a |
| Database Links | Reactome: R-HSA-1483191Reactome: R-HSA-201688Reactome: R-HSA-2514853Reactome: R-HSA-445144Reactome: R-HSA-6798695Reactome: R-HSA-6804756Reactome: R-HSA-6814122Reactome: R-HSA-8934903Reactome: R-HSA-8939243Reactome: R-HSA-8948751Reactome: R-HSA-9755511Reactome: R-HSA-9828806 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Casein Kinase Ii Subunit Beta antibodyAnti-Ck Ii Beta antibodyAnti-Phosvitin antibodyAnti-Protein G5a antibodyAnti-CSNK2B antibodyAnti-CK2N antibodyAnti-G5A antibody |
Information sourced from Uniprot.org
