Anti-Casein Kinase 2 beta antibody (1-215) (STJ11102908)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Casein Kinase 2 beta (CSNK2B) (1-215) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CSNK2B |
| Gene ID | 1460 |
| Uniprot ID | CSK2B_HUMAN |
| Immunogen Region | 1-215 |
| Immunogen Sequence | MSSSEEVSWISWFCGLRGNE FFCEVDEDYIQDKFNLTGLN EQVPHYRQALDMILDLEPDE ELEDNPNQSDLIEQAAEMLY GLIHARYILTNRGIAQMLEK YQQGDFGYCPRVYCENQPML PIGLSDIPGEAMVKLYCPKC MDVYTPKSSRHHHTDGAYFG TGFPHMLFMVHPEYRPKRPA NQFVPRLYGFKIHPMAYQLQ LQAASNFKSPVKTIR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human Casein Kinase 2 beta (CSNK2B) ) (NP_001311.3). |
Additional Info
| Post Translational Modifications | Phosphorylated by alpha subunit. |
| Function | Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling. (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML. Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcrition. |
| Protein Name | Casein Kinase Ii Subunit BetaCk Ii BetaPhosvitinProtein G5a |
| Database Links | Reactome: R-HSA-1483191Reactome: R-HSA-201688Reactome: R-HSA-2514853Reactome: R-HSA-445144Reactome: R-HSA-6798695Reactome: R-HSA-6804756Reactome: R-HSA-6814122Reactome: R-HSA-8934903Reactome: R-HSA-8939243Reactome: R-HSA-8948751Reactome: R-HSA-9755511Reactome: R-HSA-9828806 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Casein Kinase Ii Subunit Beta antibodyAnti-Ck Ii Beta antibodyAnti-Phosvitin antibodyAnti-Protein G5a antibodyAnti-CSNK2B antibodyAnti-CK2N antibodyAnti-G5A antibody |
Information sourced from Uniprot.org