Anti-CAPZB antibody (1-272) (STJ110405)

Name: Anti-CAPZB antibody (1-272) (STJ110405)
SKU: STJ110405
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ110405

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Short Description	Rabbit polyclonal CAPZB (1-272) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	CAPZB
Gene ID	832
Uniprot ID	CAPZB_HUMAN
Immunogen Region	1-272
Immunogen Sequence	MSDQQLDCALDLMRRLPPQQ IEKNLSDLIDLVPSLCEDLL SSVDQPLKIARDKVVGKDYL LCDYNRDGDSYRSPWSNKYD PPLEDGAMPSARLRKLEVEA NNAFDQYRDLYFEGGVSSVY LWDLDHGFAGVILIKKAGDG SKKIKGCWDSIHVVEVQEKS SGRTAHYKLTSTVMLWLQTN KSGSGTMNLGGSLTRQMEKD ETVSDCSPHIANIGRLVEDM ENKIRSTLNEIYFGKTKDI
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1-272 of human CAPZB (NP_004921.1).

Function	F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules.
Protein Name	F-Actin-Capping Protein Subunit Beta Capz Beta
Database Links	Reactome: R-HSA-2132295 Reactome: R-HSA-3371497 Reactome: R-HSA-6807878 Reactome: R-HSA-6811436 Reactome: R-HSA-9013405 Reactome: R-HSA-9035034 Reactome: R-HSA-9662360 Reactome: R-HSA-983231
Cellular Localisation	Cytoplasm Cytoskeleton Myofibril Sarcomere
Alternative Antibody Names	Anti-F-Actin-Capping Protein Subunit Beta antibody Anti-Capz Beta antibody Anti-CAPZB antibody

Information sourced from Uniprot.org