Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CAPN3 |
Gene ID: | 825 |
Uniprot ID: | CAN3_HUMAN |
Immunogen Region: | 70-309 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 70-309 of human CAPN3 (NP_775111.1). |
Immunogen Sequence: | EEVENTISVDRPVKKKKTKP IIFVSDRANSNKELGVDQES EEGKGKTSPDKQKQSPQPQP GSSDQESEEQQQFRNIFKQI AGDDMEICADELKKVLNTVV NKHKDLKTHGFTLESCRSMI ALMDTDGSGKLNLQEFHHLW NKIKAWQKIFKHYDTDQSGT INSYEMRNAVNDAGFHLNNQ LYDIITMRYADKHMNIDFDS FICCFVRLEGMFRAFHAFDK DGDGIIKLNVLEWLQLTMY |
Tissue Specificity | Isoform I is skeletal muscle specific. |
Function | Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53. |
Protein Name | Calpain-3Calcium-Activated Neutral Proteinase 3Canp 3Calpain L3Calpain P94Muscle-Specific Calcium-Activated Neutral Protease 3New Calpain 1Ncl-1 |
Database Links | Reactome: R-HSA-1474228 |
Cellular Localisation | CytoplasmNucleusNucleolus |
Alternative Antibody Names | Anti-Calpain-3 antibodyAnti-Calcium-Activated Neutral Proteinase 3 antibodyAnti-Canp 3 antibodyAnti-Calpain L3 antibodyAnti-Calpain P94 antibodyAnti-Muscle-Specific Calcium-Activated Neutral Protease 3 antibodyAnti-New Calpain 1 antibodyAnti-Ncl-1 antibodyAnti-CAPN3 antibodyAnti-CANP3 antibodyAnti-CANPL3 antibodyAnti-NCL1 antibody |
Information sourced from Uniprot.org